Association Serum Lipid Profile with Glutathione S- Transferas M and T genes Polymorphisms in Hypertension of Post-Menopausal Women

Fulla Abd Alsattar Alriyahee, Methaq J Al-Jboori, Mona N N Al-Terehi

Abstract


Hypertension has been the most health problem in the world; it caused morbidity and mortality by its complications, some factors contributed in incidence this disease. The present study as cried out to investigate lipid profile types levels in post menopause women suffered from hypertension. Samples and data were collected from patinas and control, then lipid profile cholesterol, High Density Lipoprotein (HDL) , Triglycerides (TG) , Low Density Lipoprotein (LDL) and Very Low Density Lipoproteins (VLDL). The results show that mean of age was 58.135±9.595 and 50.4±5.834 for patient and control respectively, body mass index was 31.61±6.86, 29.99±3.81 for patients and control respectively. More patients were overweight 48.27% and 40.54% of them have age less than 50 years. About 53.57% of patients had duration rang 5-10 years. The lipid profile levels were significant elevation in patients than control except TG , it were 447.83, 193, 414.43, 64.61 mg\dl for CHO, HDL, TG, LDL and VLDL respectively, The lipid profile levels positive associated with BMI in significant differences but didn’t association with age and duration of disease. This results concluded that there was strong association between blood pressure and lipid profile level in post- menopausal women and this related with BMI in Iraq the genotyping of GST genes GSTM and GSTT show significant differences between GSTT deletion and normal in patients and control , 83.73% of patients GSTT gene was deleted. the deletion in GSTM was high in patients than control (32.43%). Pattern of two genes which represented by two genes normal or two genes deleted show significant differences between study groups about 24.32% of patients had two genes deleted and low percentage of it (10.81%) had normal genes. When analysis normal gene with deleted gene for GSTM and GSTT , there was no significant differences between groups.

Keywords


Post- menopausal hypertension, Lipid profile, Women GSTT , GSTM.

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DOI: http://dx.doi.org/10.25258/ijpqa.10.2.5

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