Evaluation of Liver Protective Activity of Some Indigenous Plants Against Acute Paracetamol Toxicity in Rodents

Preeti Chaudhary, Shamim Ahmad, Najam Ali Khan

Abstract


Aim: The aim of the present study was to evaluate the liver protective activity of some indigenous plants against acute paracetamol toxicity in rodents. Liver intoxication was induced by paracetamol drug at a dose level of 500 mg/kg b.w, p.o for 9 days. To conduct this study the hydroalcholic extract of Prunus persica, Calotropis procera and Canscora decussate were taken as test compounds. Methods: Rats (180-200 g) were used for all the study and they were divided into 9 groups containing 6 animals each. Rats in Group I served as normal control (distilled water) group, Group II served as toxic control (Paracetamol treated) group, Group III served as standard (Silymarin) group. The rats of groups IV, V, VI, VII, VIII and IX served as test control groups. Group IV, V received the hydroalcoholic extract of Prunus persica at the dose of 200 and 400 mg/kg b.w, p.o respectively for 9 days. Group VI, VII received the hydroalcoholic extract of Calotropis procera at the dose of 200 and 400 mg/kg b.w, p.o respectively for 9 days. Group VIII and IX received the hydroalcoholic extract of Canscora decussate at the dose of 200 and 400 mg/kg b.w, p.o respectively for 9 days. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total protein and albumin. Results: Results of this study showed that the treatment of the toxic effect of the paracetamol were significantly controlled in the hydroalcoholic extract of plants treated groups. The hydroalcholic extract of plants at 400 mg/kg b.w, showed significant reduction in elevated serum enzyme levels compared to paracetamol induced toxic group. The hydroalcoholic extract of Calotropis procera at a dose of 400 mg/kg, b.w showed the most significant hepatoprotective activity among all the test groups. Conclusion: From the results it was concluded that the all the test plants extract possess significant Hepatoprotective activity which was manifested by restoration of serum biochemical parameters to nearer the normal values. On the basis of results obtained, it can also be concluded that the hydroalcoholic extract of Plants seems to have hepatoprotective activity which may be due to the presence of flavonoids.

Keywords


Prunus persica, Calotropis procera, Canscora decussate, Hepatoprotective activity, Serum enzymes, Silymarin.

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DOI: http://dx.doi.org/10.25258/ijpqa.10.2.14

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