Pharmacokinetic and Pharmacodynamic Modelling in Paediatric Bone Marrow Transplantation

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Elham Alshammari

Abstract

Building pharmacokinetics and pharmacodynamics models that describe the relationship between drug concentration and its clinical response in different disease conditions and age groups should be emphasized. This review aims to explore modelling in case of bone marrow transplantation staring from bone marrow and immune system, transplantation process, immune reconstitution and graft versus host disease, the difference in case of children, to handling of data that arise from patients.

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Research Article