Hypolipidemic Effect of Portulaca oleracea and Salvia officinalis Comparing to Atorvastatin in Rats

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Rana J Tarish
Ali M Ghazi1
Jamela K Abd-Alhassen


Non-communicable diseases (NCDS), mainly cardiovascular diseases, are considered the major reason of mortality universally. A high blood level of lipid, which also is known as hyperlipidemia, is mostly the main etiological factor in those diseases. Therefore, there is a persistent need to develop a strategy to cure this symptomless killer. Consequently, we aimed to investigate the effect of Portulaca oleracea P. oleracea and Salvia officinalis leaves ethanolic extract in mitigating hyperlipidemia in the rat. To achieve this aim, we divided 30 Wistar albino rats into 5 groups as follow; negative control group (-ve) received no treatment, positive control group (+ve) received 100mg/kg BW of triton, 1st treatment group (T1) received atorvastatin, 2nd treatment group (T2) received P. oleracea 200 mg/kg BW, 3rd treatment group (T3) received S. officinalis L. extract 200 mg/kg BW. All treatments were given orally. The results reveal that the tested plant extracts show significant hypolipidemic effect, which is statistically equal to that of the atorvastatin. In conclusion, this study suggests employing such herbal remedies to deal safely with hyperlipidemia instead of relying on chemical medicines.

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Research Article