Venlafaxine is 1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl] cyclohexan-1-ol, used as an antidepressant of the neither serotonin- nor epinephrine reuptake inhibitor (SNRI) class. It is prescribed for the treatment of clinical depression and anxiety disorders. In present work, a simple, sensitive, accurate and economical spectroscopic method has been developed for the estimation of Venlafaxine HCl in Bulk and its pharmaceutical dosage forms. An absorption maximum was found to be at 274 nm with the solvent system 0.1 N HCl. The drug follows Beer law in the range of 10-250 μg/ml with correlation coefficient of 0.9998. The percentage recovery of Venlafaxine HCl ranged from 99.97 to 100.05% in pharmaceutical dosage form. Results of the analysis were validated for accuracy, precision, LOD, LOQ and were found to be satisfactory. The proposed method is simple, rapid and suitable for the routine quality control analysis.

The aim of this study was to preparation and evaluation of carvedilol microsphere using spray drying technique and to optimize the spray drying parameters to get the optimum formulation. The carvedilol microsphere were prepared by spray drying technique using ethyl cellulose and PEG 6000 as sustained release polymers. Nine batches were prepared by using ethyl cellulose and PEG 6000 in different polymer ratios and prepared microspheres were evaluated for the particle size, percentage drug entrapment and percentage drug release.Experimental designs were built to investigate the effects of five parameters on production yields and particle size of spray-dried microspheres of carvedilol. These factors concerned aspiration speed, flow rate, drug polymer ratio, temperature difference between inlet temperature and outlet temperature. Three formulations containing ethyl cellulose, PEG 6000 and carvedilol were tested. The aim of the study was to optimize the operating conditions to maximize production yields while minimizing the particle size. The characterization of microsphere revealed the poor flowability of the spray-dried products due to significant cohesiveness and very small size (less than 20µm).