International Journal of

Pharmaceutical Quality Assurance

ISSN: 0975 9506
Peer Review Journal

doi prefix: 10.25258/ijpqa

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1. Bioanalytical Method Development and Validation of Valproate Semisodium in Human Plasma by LC–MS/MS
Bratati Roy, Bhupinder Singh, Anjana Rizal, C.P. Malik
An LC–MS method for the determination of Valproate semisodium in human plasma was developed and validated. Sample preparation involved the protein precipitation method. Chromatographic separation was performed on Sunfire C18 5µm (150 X 4.6) mm column with the mobile phase consisting of Acetonitrile: 10 mM ammonium acetate buffer ::80:20 v/v. The interface used with the API 3000 LC-MS/MS was a turbo ion spray in which negetive ions were measured in MRM mode. The method was validated over the concentration range of 1.012 µg/mL. to 120.399 µg/mL. and the Lower limit of quantitation (LLOQ) was 1.012 µg/mL. The intra- and inter-day precision of the method at four concentrations was 2.26-10.67% and 3.58-10.49% .Stability of compounds was established in a series of stability experiments. The method can be used for the simultaneous determination of Valproate semisodium in human plasma.

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